I have listed some valuable information for you to read in one easy-to-read webpage. This is a free service for our valued readers which can be located on this link: Cancer Clinical Trials
Phase I Trials: The first step in testing a new approach in humans. Data from previous animal and laboratory studies are used to evaluate drug dose, drug metabolism, administration schedule and side effects. Patients are divided into small groups called "cohorts." Each cohort is treated with increasing doses of the agent or combination until the maximal tolerated dose is reached. The highest dose associated with acceptable side effects is chosen for future studies. Generally, phase I trials are conducted on patients who have advanced disease and a variety of malignancies.
Phase II Trials: Determining the safety and effectiveness of a new treatment are the primary endpoints of phase II trials. A new drug, combination, or technique is studied on a small and relatively homogeneous group of patients. The type of cancer chosen for a phase II treatment is based on results of Phase I trials and laboratory studies. The primary purpose of most phase II cancer trials is to determine the percentage of patients that show a measurable response to treatment. Additional information on side effects and safety are also collected.
Phase III Trials: These large-scale trials compare a new treatment or combination that has shown promise in Phase II trials to the current standard therapy. Patients are randomly assigned to the standard approach. Phase III trials are critical for advancing the quality of cancer treatment and may establish a new standard of care.
